Running Head: INNATE IMMUNITY IN INFLAMMATORY POLYPS
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منابع مشابه
Nasal polyposis: an inflammatory condition requiring effective anti-inflammatory treatment.
PURPOSE OF REVIEW Recent literature in chronic rhinosinusitis with nasal polyps (CRSwNP) has focussed on inflammatory mechanisms underlying the disease. Endotyping the histopathological features of the disease, rather than simple clinical phenotypes, reflects a change in our understanding of the disease and approach to management. This is paralleled by renewed evidence for the need for wide pos...
متن کاملSinonasal epithelial cell response to Staphylococcus aureus burden in chronic rhinosinusitis.
IMPORTANCE Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and paranasal sinuses. Staphylococcus aureus is increasingly linked with CRS exacerbations. Little is known about how bacteria activate inflammatory pathways that contribute to CRS. OBJECTIVE To develop an in vitro coculture system to explore how infection with S aureus stimulates innate immune responses of sinona...
متن کاملEffect of Aloe Vera Herbal Extract on Innate Immunity in Balb/c Mice Against Candida Albicans
Background: Based on the reports, Aloe vera extract, a herbal medicine, has antimicrobial and anti-inflammatory effects. Also, this medicinal plant has considerable effects on innate immunity through cytokine secretion which resist fungal infections such as Candida albicans. Moreover, Aloe vera is considered as immunomodulatory agent and regulate inflammatory responses. Materials and Methods: I...
متن کاملRhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy.
BACKGROUND/AIMS High mobility group box 1 (HMGB1) is a protein belonging to the class of damage-associated molecular pattern molecules, which activates innate immunity and powerful inflammatory factors. The aim of this review is to show the importance of HMGB1 in the pathogenesis of nasal inflammatory diseases and to suggest that inhibition of HMGB1 may be an innovative therapeutic target. ME...
متن کاملSpontaneous Eosinophilic Nasal Inflammation in a Genetically-Mutant Mouse: Comparative Study with an Allergic Inflammation Model
BACKGROUND Eosinophilic inflammation is a hallmark of chronic rhinosinusitis with nasal polyps. To model this disease process experimentally, nasal sensitization of mice with ovalbumin or aspergillus has been described. Here, we describe a genetically mutant mouse that develops robust spontaneous nasal eosinophilic inflammation. These mice lack the enzyme SHP-1 that down-regulates the IL-4Rα/st...
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تاریخ انتشار 2014